During the COVID 19 pandemic, the effectiveness of the combination of hydroxychloroquine and azithromycin is widely discussed. This treatment can cause many severe cardiac side effects that makes us discuss its utility.
The aim of this study is to describe the cardiovascular effect of hydroxychloroquine and azithromycin by analyzing surface ECG in patients with COVID 19.
Methods: This observational cohort study included Moroccan patients with COVID 19 diagnosis and were hospitalized in Cheikh Khalifa International University Hospital, Casablanca, Morocco between March 26 and April 20, 2020.Patients were treated with a combination of hydroxychloroquine and azithromycin over a period of at least ten days. We were interested in the effects of this association on the electrocardiogram.
Results: A total of 118 eligible patients were enrolled in the study. QT interval prolongation was observed in 19% of patients under the treatment. Only 5 patients required discontinuation of treatment. The factors associated with QT prolongation are male gender (P value 0,043), age over 68 years (P value 0,09), cardiovascular comorbidity (P value 0,013), tisdale score ≥11 (P value
Conclusion:QT prolongation is a real risk with the combination of HCQ and azithromycin. In the current context, it is necessary to select patients at high risk of severe rhythm disturbances that require closer ECG monitoring. Treatment should be discontinued if there are alarming signs such as QTc prolongation beyond 550 ms and the development of ventricular extrasystole or torsade de pointe.
El Ouarradi, Amal; Abdeladim, Salma; Oualim, Sara; Bensahi, Llham; Hafid, Sara; Tazi, Hamza; Elharras, Mahassine; Aniq Filali, Rita; Nailhou, Abdelhamid; Bouaiti, El Arbi; Moustaghfir, Abdelhamid; and Sabry, Mohamed
"Hydroxychloroquine And Azithromycin As A Treatment Of Covid- 19: Electrocardiogram Variability,"
Journal of the Saudi Heart Association: Vol. 32
, Article 7.
Available at: https://doi.org/10.37616/2212-5043.1088
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