Authors

• Mohammad Ali Hammad, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Ramy Magdy Elgamal, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Arwa Mohsen Abouelkhir, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Osama Abouelfetouh Elshaer, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, EgyptFollow
• Mohamed Shokry Fahmy, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Reda Nabil Dawoud, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Reda Biomy, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt
• Mohamed Kamal Salama, Kafrelsheikh University Hospital, Department of Cardiovascular Medicine, Kafrelsheikh, Egypt

Right Ventricular–Pulmonary Artery Coupling Predicts Early Myocardial Strain Improvement in SGLT2 Inhibitor-Treated HFrEF

Abstract

Background: While sodium-glucose cotransporter-2 (SGLT2) inhibitors clearly benefit left ventricular recovery in heart failure with reduced ejection fraction (HFrEF), their rapid effects on right ventricular (RV) function remain poorly characterized. This prospective observational study investigated the timeline and markers of biventricular changes shortly after SGLT2 inhibitor initiation.

Methods:In this prospective observational study, 50 adults with HFrEF (LVEF

Results:After 3 months, NT-proBNP levels decreased significantly (1116.5 vs 913.5 pg/mL, P

Conclusions: In this prospective observational study without a control group, SGLT2 inhibitor initiation was associated with coordinated biventricular improvements within three months in HFrEF patients. The baseline TAPSE/PASP ratio may serve as a useful non-invasive predictor of early RV functional recovery. These preliminary findings require confirmation in larger controlled studies.

Recommended Citation

Hammad, Mohammad Ali; Elgamal, Ramy Magdy; Abouelkhir, Arwa Mohsen; Elshaer, Osama Abouelfetouh; Fahmy, Mohamed Shokry; Dawoud, Reda Nabil; Biomy, Reda; and Salama, Mohamed Kamal (2026) "Right Ventricular–Pulmonary Artery Coupling Predicts Early Myocardial Strain Improvement in SGLT2 Inhibitor-Treated HFrEF," Journal of the Saudi Heart Association: Vol. 38 : Iss. 2 , Article 9.
Available at: https://doi.org/10.37616/2212-5043.1504

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